PhD – Flow and rheology of complex fluids in microfluidic geometries: application to filling and injection processes of antibody solutions
High antibody concentrations in aqueous compositions are becoming increasingly important in the pharmaceutical industry in order to deliver the required high dose in as small a volume as possible. However, higher concentrations lead to an increased viscosity, affecting both production processes (pumping, filling, and filtration) and the ability to deliver such compositions (through a syringe or auto-injector). The nature of the interactions of the monoclonal antibodies (proteins) at the origin of the observed viscosity, are not fully understood yet, making its control difficult.
More information: Proposition_These_Sanofi_2015-1