GDR Micro Nano Fluidique

Mois : juin 2015

These approaches allow, for example, extracting the mRNA from a few cells and robust analysis by qRT-PCR (quantitative realtime PCR). With the advent of the study of proteomes emerged biochips development for protein research « at the molecular level. » Unfortunately no technique exists to amplify protein biomarkers and the question of their detection is crucial. The sensitivity of the detection is then limited by the sensitivity of analytical tools. Up to now protein biochips developed are based on fluorescence or electrochemical detection of target species.

More information : PostDocPositionLIONS

Ce phénomène se rencontre dans la nature, il est par exemple impliqué dans le déplacement du sucre dans les plantes, ou bien dans des applications industriels comme le dessalement, l’ultrafiltration ou bien la conversion énergétique.

Plus de détails : These_ESPCI-Total

The research is funded by the European Commission Horizon 2020 program via FET Open grant. The theoretical study will be closely coordinated with microfluidic experiments (P. Tabeling, ESPCI) and numerical modeling (L. Brandt, KTH).

More information : postdocFETOpen2015

High antibody concentrations in aqueous compositions are becoming increasingly important in the pharmaceutical industry in order to deliver the required high dose in as small a volume as possible. However, higher concentrations lead to an increased viscosity, affecting both production processes (pumping, filling, and filtration) and the ability to deliver such compositions (through a syringe or auto-injector). The nature of the interactions of the monoclonal antibodies (proteins) at the origin of the observed viscosity, are not fully understood yet, making its control difficult.

More information: Proposition_These_Sanofi_2015-1

L’augmentation du prix des ressources fossiles, l’incertitude quant à leur disponibilité à long terme et les préoccupations environnementales justifient la recherche de matières premières et de technologies alternatives capables de réduire la dépendance en ces combustibles fossiles et d’atténuer les atteintes à l’environnement, notamment en termes d’émissions de dioxyde de carbone.

Plus de détails : Sujet thèse Viollette – IEMN

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