Human induced pluripotent stem cells (hiPSCs) hold great potential for regenerative medicine, disease modeling, and drug discovery. Rapid progress has been made during the last 12 years but it is still challenging to produce high quality hiPSCs and their derivatives for industrial and clinic applications due to risks of gene instability and tumorigenicity. To solve the problem, we proposed a patch method by mimicking the in-vivo basement membrane and/or extracellular matrix with a monolayer of nanofibers, allowing a better control of spheroids formation and hiPSC differentiation. We also proposed a device configuration for easy patch and microfluidic integration. Finally, we initiated an auto-culture system for the long-term control of hiPSCs culture and differentiation conditions.
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