GDR Micro Nano Fluidique

Mois : juin 2018

Cette thèse s’attache à développer des matériaux poreux conducteurs biocompatibles et déformables en vue de l’élaboration de bioréacteurs enzymatiques ou cellulaires à plus long terme. La conductivité permettra alors de créer in situ une interface électrochimique destinée à la connexion électrique d’enzymes pour la réalisation de biocapteurs hautement sensibles dont la réponse peut être amplifiée par le confinement. On peut aussi envisager leur utilisation pour le suivi de la culture cellulaire dans son volume.

Plus d’informations : Proposition-de-these-ENSAIT_CEA-v2.docx

Context : the project MEDICAPLUS is a new CEA collaboration composed of biologists and physicist to work on the development of a novel digital autoradiography analyzer. The aim of the project is to build a detector prototype able to quantify the exact dose of the tritium-labeled drugs after in vivo administration to cell population.
One part of the project is related to microfluidics and specifically dedicated to the development of a microfluidic system for single cell trapping and further beta-imaging.

More information : CDD_MedicaPlus_LIONS_SIMOPRO.pdf

Astraveus is a two-year old start-up developing microfluidic automation for the production of cell and gene therapies (CGTs). These new kinds of therapies have tremendous potential, for example to cure cancers, but their accessibility is limited by industrial capacity and production cost. With several innovative and very high-performance technologies we aim at both bringing cost reduction and scale-up of CGT so that many more patients can be treated.

More information : RD-Engineer-Final-2018-1.pdf

Mission
This project proposed the development of a microfluidic system for mutation monitoring. The system will allow the growth of yeast populations over 100 generations through population bottlenecks and the analysis of the mutation spectrum in different genetic contexts by high-throughput sequencing (NGS). The successful candidate will contribute to the design, the microfabrication, and the optimization of the microsystem, to the measurement campaigns and to the data analysis. The candidate will mainly works in the LIONS for the microsystem development but he/she will be in close collaboration with the biologists of the SBIGeM.

More information : CDD_MutMonitor.pdf

Context : The project described here is part of the work carried out by the CEA concerning present and future processes for the treatment/recycling of spent nuclear fuels. The study and development of these processes require many steps, from design in the laboratory through to setting up on an industrial scale. In all of these steps, analysis and instrumentation are key points.

More information : English_Postdoc_CEA_µfluidique_Proposal.pdf

Plus d’informations : Francais_Postdoc_CEA_µfluidique_Proposition.pdf

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