GDR Micro Nano Fluidique

Mois : avril 2019

Magnetic nanoparticles have grown considerably over the last decade. The field of detection and
actuation of magnetic nanoparticles in microfluidic systems for applications in biological analysis is already
of interest to several laboratories at the international level [1‐4]

Sujet_de_these_19_anglais_L2E_Lab_On_Chip_Immuno

Environnement de travail
Le L2n fait partie de l’Université de technologie de Troyes. Plus de 80 personnes (enseignants chercheurs, ingénieurs, post doctorant et doctorants) travaillent sur la nano-optique, la plasmonique moléculaire, la photonique et la nanobiophotonique. Les équipements du laboratoire sont composés d’une plateforme de fabrication dévolue aux nanostructures (salle blanche, lithographie optique, RIE, évaporateur, MEB etc etc), de microscopes optiques, d’AFM, de lasers ultrarapides etc etc.

PhD-space_int

Different regions of the body have different physico-chemical characteristics, resulting notably in
various sources of confinement and mechanical stresses that C. albicans cells may experience.
Recently, we have shown that the switch from one morphotype to another one was highly
dependent on mechanics, raising the question of the role of such stresses in promoting or
restraining virulence.

mecalbicans-offer

 

Context and Objectives
Understanding the phenomena involved in gas microflows is of crucial interest for the development of new and innovative fluidic microsystems. Gas flows in such systems find nowadays more and more industrial applications in numerous fields such as environment, electronics, aerospace engineering…

PhD position_2019_MTT

La plate-forme de chimie biologique intégrative de Strasbourg (PCBIS) est une unité mixte de service (UMS 3286) CNRS-unistra centrée sur la découverte de molécules bioactives. Situés à l’interface d e la chimie et la biologie nous sommes amenés àdévelopper de multiples projets impliquant la technologie de microfluidique.

poste microfluidique

 

This makes Cyprio the holder of a unique technology (BioPearl) for fabrication of spheroids that are physiologically more relevant than traditional monolayer models and are compatible with high throughput screening applications. Our first product, HepatoPearl, has been validated as a beneficial in vitro hepatic model for various applications, such as screening
of drug-drug interactions, in vitro toxicology and metabolism of low clearance compounds. Currently, Cyprio is expanding its product range by using its breakthrough technology to definitively change liver cell-culture biology approaches towards more complex and more relevant, yet more robust, easier to handle and HTS compatible 3D cellular models.

https://www.gdrmicrofluidique.com/production-engineer-w-m-cyprio/

 

Created in 2017, CYPRIO is based on more than ten years of research and development at the School of Industrial Physics and Chemistry in Paris (ESPCI) and has solid expertise in the fields of biomaterial physicochemistry, liver biology and drug screening. This makes Cyprio the holder of a unique technology (BioPearl) for fabrication of spheroids that are
physiologically more relevant than traditional monolayer models and are compatible with high throughput screening applications.

Cyprio_Ingénieur_production_EN

 

Description de projet :
La société CYPRIO est spécialisée dans la culture en 3D des cellules de mammifères, plus
précisément du foie et du pancréas. Une technologie d’encapsulation (brevet de la
société) permet la production de capsules miniaturisées à haut débit, permettant la
culture des cellules en 3D tout en conservant leurs propriétés biologiques.

Cyprio_Annonce_stage_FR

 

Référence : UMR5221-ADRNOU-001
Lieu de travail : MONTPELLIER
Date de publication : jeudi 14 mars 2019
Type de contrat : CDD Scientifique
Durée du contrat : 24 mois
Date d’embauche prévue : 2 septembre 2019
Quotité de travail : Temps complet
Rémunération : 2530 à 3510 brut selon expérience
Niveau d’études souhaité : Doctorat
Expérience souhaitée : Indifférent