The two main objectives of this post-doc stay are:
1. Work in the design and characterization of a state-of-the-art microfluidic platform enabling a full control of both the mechanical and the chemical.
2. Investigate the role of mechanical stress, coupled to chemical signaling, in promoting the epithelialto-mesenchymal transition.
More information : PDoc-cancer-mecha.pdf
In tight collaboration with Grenoble Hospital, LETI and BIG institutes open 5 postdoctoral positions to hire young researchers willing to contribute their expertise and enthusiasm at the service of an ambitious « Pancreas-on-Chip » multidisciplinary project. This project applies a range of interdisciplinary technologies and advanced approaches in microfluidics, 3D bioprinting, stem cells, and nanomaterials, to engineer devices that can recapitulate functional units of human pancreas.
More information : Post-doc-LETI_OOC1_2018.pdf
The goal of the project is to propose a solution based on microfluidics. The idea is to use microfluidic systems, incorporating arrays of membranes, with pressure controlled deflections. Such a system has the capacity to focus light under fine control, while working in the appropriate range of focal lengths.
More information : Opening-postdoc-THALES.docx
In collaboration with other teams at CEA, the candidate will have to develop and characterize two microfluidic devices for biological entities sorting. The candidate will work on two devices. One to sort in size cell clusters called Langerhans islets involved in the insulin secretion. This task is part of a cell therapy project for type I diabetes aimed at grafting allogenic encapsulated islets to restore glucose regulation with limited or no immuno-suppressive treatments. The other one is related to the sorting of viruses from a plasma sample and their conditioning for subsequent nebulization and detection. It requires both the development and characterization of sorting devices, and their implementation on a fluidic cartridge.
More information : EN_CEA_PhD-Post-doctoral-position_sorting.pdf
The principle of osmotic compression is shown in Fig 1(a). A dilute formulation contained within a milliliter dialysis bag is immerged within a reservoir containing a stressing solution (generally polymers). The porosity of the dialysis membrane retains large colloidal species (10-1000 nm), but still allows fluxes of solvent and molecular solutes. The osmotic pressure difference across the membrane then drives a flow to equilibrate chemical potentials of the molecular species. Besides providing an easy way to concentrate dilute formulations without tedious hand-made mixing, this technique also leads to estimates of the equation of state of the complex fluid, i.e. the relation between the osmotic pressure pi and composition.
More information : AffichePostDocOSMOCHIP.pdf