This project sits at the junction between microfabrication and biology.

On the biology side, we wish to investigate the role played by the circadian clock in muscle regeneration. Circadian rhythm are known to play a significant part in several key aspects of our physiology by optimizing our metabolism to the various task it must typically accomplish at specific times of the day. The disturbances induced by our lifestyles on this clock have been shown to produce a wide range of diseases. This project will investigate the interplay between the metabolism of specific muscle cell lines and a key component of our circadian clock: Rev-erbα In particular, we will try to address the question: does the time of injury or the time of stem cell injection plays a part in the subsequent healing process?

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