Scientific field and context: The diagnosis of most pathologies is currently carried out on the basis of biomolecular tests. However, in the context of point of care diagnostic, where low-cost devices are needed, these techniques suffer from certain limitations. Indeed, the use of biomolecular reagents can be quite expensive, requires strict conservation conditions and imposes a limited life of the device. To overcome these disadvantages, it is necessary to develop new approaches exploiting the physical properties (mechanical, electrical or migratory properties of cells). This thesis aims to provide an innovative approach to perform a diagnosis through the combination of nanophotonics and microfluidics. It is based on an optical measurement of the deformability of individual cells, which is an indicator for pathologies such as malaria, cancer, sepsis, etc…

More information : Thesis-INL-Benyattou-Faivre.pdf