A major challenge in cancer research is the complexity of the tumor microenvironment which includes the host immune cells. Inspired by the emerging technology of organ-on-chip, we achieved 3D cocultures in microfluidic devices (integrating four cell populations: cancer, immune, endothelial and fibroblast) to reconstitute and visualize ex vivo human tumor ecosystems. These tumors-on-chip are powerful novel platforms to study ex vivo immunocompetent tumor microenvironments, to characterize ecosystem-level drug responses, and to dissect the roles of stromal components.

More information : Post-doc-position-at-Institut-Curie_Paris-vf.pdf