Post-doctoral position in Cancer Cell Biology at Institut Curie – Paris
A major challenge in cancer research is the complexity of the tumor microenvironment which includes the host immune cells. Inspired by the emerging technology of organ-on-chip, we achieved 3D cocultures in microfluidic devices (integrating four cell populations: cancer, immune, endothelial and fibroblast) to reconstitute and visualize ex vivo human tumor ecosystems. These tumors-on-chip are powerful novel platforms to study ex vivo immunocompetent tumor microenvironments, to characterize ecosystem-level drug responses, and to dissect the roles of stromal components.
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