The goal of this project is to design and set-up a microfluidic device that mimics the characteristics of a blood microcirculation network. Capillaries are watertight conduits lined with endothelial cells surrounded by extracellular matrix with a 10 µm-wide lumenand organize in complex networks. These small vessels are submitted to various biophysical stimuli such as shear stress, pressure or oxygen concentration. In addition, different cell types such as pericytes and immune cells participate in the biology of these vessels. This microfluidic system will be designed to reproduce the 3- dimensional geometry of capillaries and precisely control their environment.

More informations : Projet microfluidique