Trypanosomes are parasites infecting mammals with severe therapeutic and economic consequences in African countries. While it is known that during trypanosome infection sudden changes of membrane proteins are responsible for the adaptation of the parasite to the immune system response, very little is known on the variability in trypanosome activity in the blood. One of the mechanism of action of the trypanosome is mediated by the release of Phospholipase in the blood stream causing damages to the red blood cell. We want to provide quantitative measurements of the activity of trypanosomes at the single cell level for a deeper understanding of the dynamics of the disease.

more information : PhDoffer