This project proposed the development of a microfluidic system for mutation monitoring. The system will allow the growth of yeast populations over 100 generations through population bottlenecks and the analysis of the mutation spectrum in different genetic contexts by high-throughput sequencing (NGS). The successful candidate will contribute to the design, the microfabrication, and the optimization of the microsystem, to the measurement campaigns and to the data analysis. The candidate will mainly works in the LIONS for the microsystem development but he/she will be in close collaboration with the biologists of the SBIGeM.

More information : CDD_MutMonitor.pdf