Post-doc position in Circulating Biomarkers Analysis Paris FRANCE
Déposé le : 26/11/2018
The MMBM is involved in two FET OPEN EU projects aiming at developing innovative technologies for tumoral circulating biomarkers analysis (ctDNA and exosomes). In particular our team is involved in developing microfluidic approaches to perform tumoral biomarkers extraction and preconcentration, one of the major bottleneck of the bioanalytical workflow.Détail
This extraction step will be performed using a technology recently pioneered by our team: a microfluidic and magnetic fluidized bed. Fluidized-beds are commonly used to enhance surface interactions in a solid/liquid mixture, with high stirring and low backpressure. Our team developed a completely new concept of micro-fluidized beds based on magnetic micro-particles in equilibrium between flow-induced drag forces and magnetic forces . This system already showed unprecedented efficiency for solid phase extraction and was successfully applied for bacteria analysis  and proteins preconcentration .
More information : Post-doc-Index-catchU-1.docx
PostDoc/PhD open positions in Nanofluidics
Déposé le : 16/11/2018
Dr. Alberto Giacomello (La Sapienza, Roma), has opened job positions (on ERC funding) on the following topic:
"Hydrophobic Gating in nanochannels: understanding single channel mechanisms for designing better nanoscale sensors"
Postdoctoral research associate
Déposé le : 14/11/2018
"Microfluidic study of the biophysics of bacterial populations in porous media."Détail
Context : This PDRA is part of a large project (BEBOP, 2019-2024) funded by the European Research Council. The goal of BEBOP is to figure out how we can use bacteria to control the properties of porous structures (e.g. porosity, permeability). We envision that this will unlock a new generation of biotechnologies, such as self-repairing construction materials or self-cleaning bioreactors. The main scientific obstacle to this technology is the lack of understanding of the biophysical mechanisms associated with the development of bacterial populations within complex porous structures. Therefore, the first scientific objective of BEBOP is to gain insight into how fluid flow, transport phenomena and bacterial communities (biofilms) interact within connected heterogeneous structures. To this end, we will combine microfluidic and 3D printed micro-bioreactor experiments; fluorescence and X-ray imaging; high performance computing bringing together CFD, individual-based models and pore network approaches. The second scientific objective of BEBOP is to create the primary building blocks toward a control theory of bacteria in porous media and to construct a demonstrator bioreactor for permeability control.
More information : BEBOP_PDRA_Microfluidics.pdf
CDD/Post-doctoral position in microfluidic
Déposé le : 12/11/2018
Sorting of biological componentsDétail
In collaboration with other teams at CEA, the candidate will have to develop and characterize two microfluidic devices for biological entities sorting. The candidate will work on two devices. One to sort in size cell clusters called Langerhans islets involved in the insulin secretion. This task is part of a cell therapy project for type I diabetes aimed at grafting allogenic encapsulated islets to restore glucose regulation with limited or no immuno-suppressive treatments. The other one is related to the sorting of viruses from a plasma sample and their conditioning for subsequent nebulization and detection. It requires both the development and characterization of sorting devices, and their implementation on a fluidic cartridge.
More information : EN_CEA_Post-doctoral-position_Sorting_Bio_Components_09112018.pdf
Post-doctoral position 2019
Déposé le :
Autonomous microfluidic oscillators for continuous flow colorimetric analysis of water samplesDétail
The project will consist in the development of an autonomous microfluidic oscillator for the continuous determination of nitrate levels by a colorimetric assay. Experimental validation for nitrate quantification will be performed in synthetic and natural waters. The study, development and fabrication of the system will be performed at the LAAS-CNRS, while the laboratory and field validations will be performed in close collaboration with the GET laboratory.
More information : Post-doc-position-2019-OSCILLEAU.pdf